Reaktion #4687

Reaktionsgleichung

4-Cyano-2(R,S)-α-naphthoxybutyric acid

KOH

α-naphthoxymalonic acid diethyl ester

acrylonitrile

→

(2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine
2. 2
   Trocknendried over sodium sulphate
3. 3
   Einengenconcentrated by evaporation

Vorschrift

4-Cyano-2(R,S)-α-naphthoxybutyric acid: 0.11 ml of a 50% aqueous KOH solution is added at 0°, while stirring, to a mixture of 5.0 g of α-naphthoxymalonic acid diethyl ester and 1.09 ml of acrylonitrile. The reaction mixture is stirred for 5 days at room temperature and then dissolved in ethyl acetate. The ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine, dried over sodium sulphate and concentrated by evaporation, leaving (2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester.

Quelle