Reaktion #468538

ord-fbe0f19cb0704256bae30c943687b702

Reaktionsgleichung

CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1
6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid
CC(C)[C@@H](N)CO
(R)-(−)-2-amino-3-methyl-1-butanol
→
CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)N[C@@H](CO)C(C)C)cn2)CC1
desired compound
Ausbeute 73.0%
CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)N[C@@H](CO)C(C)C)cn2)CC1
5-[N-[(1R)-2-hydroxy-1-isopropylethyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine
Ausbeute 73.0%

Edukte

CC(C)Nc1cccnc1N1CCN(C(=O)c2ccc(C(=O)O)cn2)CC1
6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid
CC(C)[C@@H](N)CO
(R)-(−)-2-amino-3-methyl-1-butanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeBy the same procedure as described in the example 1, synthesis
  2. 2
    SonstigeThen, the product was recrystallized with acetone and hexane

Vorschrift

By the same procedure as described in the example 1, synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using (R)-(−)-2-amino-3-methyl-1-butanol. Then, the product was recrystallized with acetone and hexane to give a desired compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06306860B1uspto-grants-2001_10