Reaktion #468313

ord-79082685ffe14e20ae1b3810b3d7d728

Reaktionsgleichung

C[Si](C)(C)C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
dibenzyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine
C[Si](C)(C)C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
Intermediate 128
C[Si](C)(C)C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
dibenzyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
Dibenzyl-[1-(4-Ethynylphenyl)-cyclopropyl]-amine

Edukte

—
alkyne
C[Si](C)(C)C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
dibenzyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine
C[Si](C)(C)C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
Intermediate 128
C[Si](C)(C)C#Cc1ccc(C2(N(Cc3ccccc3)Cc3ccccc3)CC2)cc1
dibenzyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine
O=C([O-])[O-].[K+].[K+]
potassium carbonate

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using General Procedure E; dibenzyl-[1-(4-trimethylsilanylethynylphenyl)-cyclopropyl]-amine (Intermediate 128, 100.0 mg, 0.26 mmol) in methanol (5 mL) was treated with potassium carbonate (60.0 mg, 0.44 mmol) and stirred overnight at ambient temperature. The crude alkyne (80 mg, 99%) was used directly in the next reaction.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06303785B1uspto-grants-2001_10