Reaktion #46811

Reaktionsgleichung

1-(4-Amino-phenyl)-1H-pyridin-4-one

NaHCO3

H2O

2-Trichloromethyl-1H-benzoimidazole

→

1H-Benzoimidazole-2-carboxylic acid [4-(4-oxo-4H-pyridin-1-yl)-phenyl]-amide

Lösungsmittel

THF

CH2Cl2

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with 40 mL of a saturated NaHCO3-solution
2. 2
   ExtraktionThe aqueous solution was extracted with CH2Cl2 (3×200 ml)
3. 3
   Trocknenthe combined organic layers were dried over MgSO4
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   Sonstigeto give a brown solid, which

Vorschrift

A solution of 769 mg 2-Trichloromethyl-1H-benzoimidazole in 10 mL THF were slowly added to a mixture containing 304 mg 1-(4-Amino-phenyl)-1H-pyridin-4-one, 1.3 g NaHCO3, 40 mL THF and 15 mL H2O. The mixture was stirred vigorously for 3 h at room temperature, diluted with 200 mL CH2Cl2 and washed with 40 mL of a saturated NaHCO3-solution. The aqueous solution was extracted with CH2Cl2 (3×200 ml) and the combined organic layers were dried over MgSO4 and concentrated under reduced pressure to give a brown solid, which was pure enough for the following reactions.

Quelle