Reaktion #46805

Reaktionsgleichung

1H-Benzoimidazole-2-carboxylic acid

4-(4-Amino-phenyl)-morpholin-3-one

BOP-Cl

NEt3

→

1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

Lösungsmittel

DCM

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitated product was collected by filtration
2. 2
   SonstigeThe crude product was subjected to the next reaction step without further purification

Vorschrift

To a solution of 100 mg 1H-Benzoimidazole-2-carboxylic acid and 118 mg 4-(4-Amino-phenyl)-morpholin-3-one in 2 mL DCM, 157 mg BOP-Cl and 0.3 mL NEt3 were added and the mixture was stirred for 16 h at RT. Then, after the reaction mixture was diluted with 20 mL water, the precipitated product was collected by filtration. The crude product was subjected to the next reaction step without further purification. Yield: 122 mg.

Quelle