Reaktion #46804

Reaktionsgleichung

4-(4-Nitro-phenyl)-morpholin-3-one

→

4-(4-Amino-phenyl)-morpholin-3-one

Lösungsmittel

ethyl acetate

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe reaction mixture was heated
2. 2
   Temperaturto reflux for 2 h
3. 3
   FiltrationThe precipitated product was collected by filtration
4. 4
   Sonstigewas pure enough for the next reaction step

Vorschrift

To a solution of 2.6 g 4-(4-Nitro-phenyl)-morpholin-3-one in 350 mL ethyl acetate and 17 mL ethanol, 13.2 g SnCl2 dihydrate were added and the reaction mixture was heated to reflux for 2 h. Then, after cooling to RT the mixture was stirred for 16 h. The precipitated product was collected by filtration and was pure enough for the next reaction step. Yield: 2.07 g.

Quelle