Reaktion #467981

Reaktionsgleichung

2′-chloro-5′-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4′-fluoroacetanilide

potassium carbonate

dimethylsulfate

→

title product

Ausbeute 85.9%

2′-Chloro-5′-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4′-fluoroacetanilide

Ausbeute 85.9%

Lösungsmittel

water

chloroform

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 90 minutes
2. 2
   EinengenThe resultant mixture is concentrated in vacuo
3. 3
   Sonstigeto obtain an aqueous suspension which
4. 4
   Filtrationis filtered

Vorschrift

A mixture of 2′-chloro-5′-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4′-fluoroacetanilide (0.85 g, 2.3 mmol), potassium carbonate (0.32 g, 2.3 mmol) and dimethylsulfate (0.22 mL, 2.3 mmol) in tetrahydrofuran is refluxed for 90 minutes, cooled to room temperature, and diluted with water and chloroform. The resultant mixture is concentrated in vacuo to obtain an aqueous suspension which is filtered to give the title product as an off-white solid (0.75 g, mp 257-258.5° C.).

Quelle