Reaktion #467980

Reaktionsgleichung

5′ -amino-2′-chloro-4′-fluoroacetanilide

2-dimethylamino-4-(trifluoromethyl)-6H-1,3-oxazin-6-one

→

title product

Ausbeute 78.1%

2′-Chloro-5′-[3,6-dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4′-fluoroacetanilide

Ausbeute 78.1%

Lösungsmittel

water

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis refluxed for 90 minutes
2. 2
   FiltrationThe resultant aqueous mixture is filtered

Vorschrift

A mixture of 5′ -amino-2′-chloro-4′-fluoroacetanilide (1.0 g, 4.9 mmol) and 2-dimethylamino-4-(trifluoromethyl)-6H-1,3-oxazin-6-one (1.0 g, 4.9 mmol) in acetic acid is refluxed for 90 minutes and diluted with water. The resultant aqueous mixture is filtered to obtain the title product as an off-white solid (1.4 g, mp 264-266° C.) which is identified by 1H, 13C and 9F NMR spectral analyses.

Quelle