Reaktion #467940

ord-b39b3b148c1a44bbb3df80ba7836608f

Reaktionsgleichung

CCOC(C)=O
ethyl acetate
O
water
Cc1ccccc1-c1cc(Cl)ncc1C(=O)NCc1ccccc1
N-benzyl-6-chloro-4-o-tolyl-nicotinamide
C1COCCN1
morpholine
→
Cc1ccccc1-c1cc(N2CCOCC2)ncc1C(=O)NCc1ccccc1
N-benzyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide
Ausbeute 100.0%

Edukte

CCOC(C)=O
ethyl acetate
O
water
Cc1ccccc1-c1cc(Cl)ncc1C(=O)NCc1ccccc1
N-benzyl-6-chloro-4-o-tolyl-nicotinamide
C1COCCN1
morpholine

Reagenzien

Keine

Lösungsmittel

O.[Cl-].[Na+]
brine

Reaktionsbedingungen

Temperatur
100°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturAfter cooling to room temperature

Vorschrift

A mixture of 5.0 g (14.8 mMol) of N-benzyl-6-chloro-4-o-tolyl-nicotinamide and 25 ml morpholine was heated to 100° C. for 3.5 hours. After cooling to room temperature, extractive work-up with ethyl acetate, water and brine gave 5.7 g (100%) N-benzyl-6-morpholin-4-yl-4-o-tolyl-nicotinamide as a yellow powder.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06303790B1uspto-grants-2001_10