Reaktion #4679

Reaktionsgleichung

2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenylidene)acetylacetate

2-isopropylthioethyl 3-aminocrotonate

ethanol

→

2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-isopropylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

Ausbeute 42.0%

Reaktionsbedingungen

Vorschrift

12 g (0l03 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenylidene)acetylacetate and 5.92 g (0.03 moles) of 2-isopropylthioethyl 3-aminocrotonate are heated under reflux in 30 ml of ethanol for 8 hours. The solution is then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-isopropylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in aqueus ethanol--at 142°-144° C. The yield was 42% of the theoretical yield.

Quelle