Reaktion #46787

Reaktionsgleichung

5-Chloro-pyridin-2-ylamine

pyridine

bromo-acetyl bromide

→

2-Bromo-N-(5-Chloro-pyridin-2-yl)-acetamide

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added dropwise under ice cooling
2. 2
   SonstigeAfter 2 h the precipitate was isolated by filtration
3. 3
   Sonstigerecrystallized from toluene
4. 4
   Sonstigeto yield a white solid

Vorschrift

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

Quelle