Reaktion #46768

Reaktionsgleichung

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

Ausbeute 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

Ausbeute 98.3%

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 100 mL round bottom flask equipped with a stir bar
2. 2
   Waschenwashed with water (3×100 mL)
3. 3
   TrocknenOrganic layer was dried over anhydrous sodium sulfate
4. 4
   Einengenconcentrated under reduced pressure

Vorschrift

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

Quelle