Reaktion #46767

Reaktionsgleichung

DIEA

2-Amino-1-phenyl-ethanol

HCl

Menthoyl chloride

→

title compounds

Ausbeute 85.0%

2-Isopropyl-5-methyl-cyclohexanecarboxylic acid (2-hydroxy-2-phenyl-ethyl)-amide

Ausbeute 85.0%

Lösungsmittel

CH2Cl2

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 500 mL round bottom flask equipped
2. 2
   workup.ADDITIONOnce the addition
3. 3
   Temperaturto warm to ambient temperature
4. 4
   workup.STIRRINGstirred 2 h
5. 5
   workup.STIRRINGstirred for an additional 20 min
6. 6
   SonstigeThe heterogeneous mixture was transferred to a separatory funnel
7. 7
   Sonstigewhere the aqueous phase was separated
8. 8
   Extraktionre-extracted with CH2Cl2 (2×100 mL)
9. 9
   Waschenwashed with 1N HCl (8×100 mL), H2O (1×100 mL), 1N NaOH (2×100 mL), brine (100 mL)
10. 10
    Trocknendried over MgSO4
11. 11
    Filtrationfiltered
12. 12
    Einengenconcentrated under reduced pressure
13. 13
    WaschenThe residue was eluted through a plug of silica gel (50% ethyl acetate/hexane for elution)

Vorschrift

A 500 mL round bottom flask equipped with stir bar was charged with CH2Cl2 (200 mL), DIEA (28 g, 0.219 mol), and 2-Amino-1-phenyl-ethanol (10 g, 0.073 mol) and cooled to 0° C. Menthoyl chloride (14.8 g, 0.073 mol) was added drop wise over a 15 min period. Once the addition was complete the reaction was allowed to warm to ambient temperature and stirred 2 h. CH2Cl2 (100 mL) and 1N HCl (100 mL) was added to the reaction mixture and stirred for an additional 20 min. The heterogeneous mixture was transferred to a separatory funnel where the aqueous phase was separated and re-extracted with CH2Cl2 (2×100 mL). The organic phases were combined and washed with 1N HCl (8×100 mL), H2O (1×100 mL), 1N NaOH (2×100 mL), brine (100 mL), dried over MgSO4, filtered and concentrated under reduced pressure. The residue was eluted through a plug of silica gel (50% ethyl acetate/hexane for elution) provided the title compounds as colorless solid (18.8 g, 85%).

Quelle