Reaktion #467259

Reaktionsgleichung

water

compound

3-(4-methoxyphenylthio)propionic acid

N-t-butoxycarbonyl-N-t-butoxycarbonyloxyamine

EDC hydrochloride

→

title compound

Ausbeute 98.8%

N-t-butoxycarbonyl-N-t-butoxycarbonyloxy-3-(4-methoxyphenylthio)propionamide

Ausbeute 98.8%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionit was extracted with ethyl acetate
2. 2
   WaschenThe extract was washed with a saturated aqueous solution of ammonium chloride
3. 3
   Trocknena saturated aqueous solution of sodium bicarbonate, a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated

Vorschrift

To a solution of the compound prepared in Example 8(11) (106 mg) in DMF (5 ml), N-t-butoxycarbonyl-N-t-butoxycarbonyloxyamine (120 mg), EDC hydrochloride (106 mg) and 4-(dimethylamino)pyridine (6 mg) were added at 0° C. The mixture was stirred for 16 hours at room temperature. To the reaction solution, water was added and it was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of ammonium chloride, a saturated aqueous solution of sodium bicarbonate, a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the title compound (211 mg) having the following physical data.

Quelle