Reaktion #466963

ord-2dbad3c5a0b04aa1ba7e027f248eca13

Reaktionsgleichung

CCOC(=O)n1c(C(=O)c2ccc3ccccc3c2)c(N)c2ccc(Cl)cc21
3-amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole
CCOC(=O)n1c(C(=O)c2ccc3ccccc3c2)c(N)c2ccc(Cl)cc21
3-Amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole
CCOC(C)=O
ethyl acetate
→
CCOC(=O)n1c(C(=O)c2ccc3ccccc3c2)c(NC(C)=O)c2ccc(Cl)cc21
title compound
CCOC(=O)n1c(C(=O)c2ccc3ccccc3c2)c(NC(C)=O)c2ccc(Cl)cc21
3-Acetylamino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole

Edukte

CCOC(=O)n1c(C(=O)c2ccc3ccccc3c2)c(N)c2ccc(Cl)cc21
3-amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole
CCOC(=O)n1c(C(=O)c2ccc3ccccc3c2)c(N)c2ccc(Cl)cc21
3-Amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole
CCOC(C)=O
ethyl acetate

Reagenzien

Keine

Lösungsmittel

—
hexanes

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to the procedure described in step 1 of Example 2 (Method A) from 3-amino-6-chloro-1-(ethoxycarbonyl)-2-(2-naphthoyl)indole (step 1). tlc: Rf =0.6 (50% ethyl acetate in hexanes)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06300363B1uspto-grants-2001_10