Reaktion #466918

ord-3792d017760e42cfa714aa1767de346b

Reaktionsgleichung

CCOC(=O)n1c(C(=O)c2ccccc2Cl)c(NC(C)=O)c2ccc(Cl)cc21
3-acetylamino-6-chloro-2-(2-chlorobenzoyl)-1-(ethoxycarbonyl)indole
CCOC(=O)n1c(C(=O)c2ccccc2Cl)c(NC(C)=O)c2ccc(Cl)cc21
3-Acetylamino-6-chloro-2-(2-chlorobenzoyl)-1-(ethoxycarbonyl)indole
[Br-].[K+]
KBr
→
CC(=O)Nc1c(C(=O)c2ccccc2Cl)[nH]c2cc(Cl)ccc12
title compound
CC(=O)Nc1c(C(=O)c2ccccc2Cl)[nH]c2cc(Cl)ccc12
3-Acetylamino-6-chloro-2-(2-chlorobenzoyl)indole

Edukte

CCOC(=O)n1c(C(=O)c2ccccc2Cl)c(NC(C)=O)c2ccc(Cl)cc21
3-acetylamino-6-chloro-2-(2-chlorobenzoyl)-1-(ethoxycarbonyl)indole
CCOC(=O)n1c(C(=O)c2ccccc2Cl)c(NC(C)=O)c2ccc(Cl)cc21
3-Acetylamino-6-chloro-2-(2-chlorobenzoyl)-1-(ethoxycarbonyl)indole
[Br-].[K+]
KBr

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to the procedure described in step 2 of Example 2 (Method A) from 3-acetylamino-6-chloro-2-(2-chlorobenzoyl)-1-(ethoxycarbonyl)indole (step 1). 1H-NMR (CDCl3) δ: 9.58 (1H, br s), 8.51 (1H, br s), 8.19 (1H, d, J=8.8 Hz), 7.52-7.03 (6H, m), 2.18 (3H, s) IR (KBr) ν: 3300, 1680, 1620, 1580, 1540, 1340, 1320, 1240, 1060, 1020, 920, 760, 740 cm−1

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06300363B1uspto-grants-2001_10