Reaktion #46691

Reaktionsgleichung

3-(4-Pyridylmethylideneamino)propionic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide

→

compound

Ausbeute 36.0%

3-(4-Pyridylmethylamino)propionic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide

Ausbeute 36.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe 10% palladium on carbon was filtered out
2. 2
   Einengenthe filtrate was concentrated under reduced pressure
3. 3
   Sonstigethe concentrate was purified by silica gel column chromatography

Vorschrift

3-(4-Pyridylmethylideneamino)propionic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide (Compound No. 21-1, 1.6 g, 3.9 mmol) was dissolved in methanol, 10% palladium on carbon (catalytic amount) was added to the solution, and the mixture was stirred at room temperature under hydrogen at 1 atm for seven hours. The 10% palladium on carbon was filtered out, the filtrate was concentrated under reduced pressure, and the concentrate was purified by silica gel column chromatography to give the target compound (0.58 g, 36%) as an oily matter.

Quelle