Reaktion #46680

Reaktionsgleichung

1-[2-(1-adamantyl)ethyl]-1-[2-[N-(t-butoxycarbonyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea

hydrogen chloride

→

1-[2-(1-Adamantyl)ethyl]-1-(2-methylaminoethyl)-3-[3-(4-pyridyl)propyl]urea dihydrochloride

Lösungsmittel

Methanol

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with a calcium chloride tube
2. 2
   workup.STIRRINGthe whole was stirred for one day
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   Sonstigeto give the target compound (0.30 g

Vorschrift

Methanol (4.4 ml) was added to 1-[2-(1-adamantyl)ethyl]-1-[2-[N-(t-butoxycarbonyl)-N-methylamino]ethyl]-3-[3-(4-pyridyl)propyl]urea (Compound No. 1-26, 0.30 g, 0.60 mmol), and the mixture was stirred at room temperature in a vessel equipped with a calcium chloride tube. A 10% solution of hydrogen chloride in methanol (4.4 ml) was added to the mixture, and the whole was stirred for one day and then concentrated under reduced pressure to give the target compound (0.30 g, quantitatively) as pale yellow amorphous powder.

Quelle