Reaktion #4667

Reaktionsgleichung

water

sodium hydride

ethyl 3-cyclopropylamino-2-(2,5-difluoro-4-pyrrol-1-ylbenzoyl)acrylate

→

product

Ausbeute 77.3%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylate

Ausbeute 77.3%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITleft
2. 2
   Temperaturto cool
3. 3
   Filtrationthe precipitate is filtered off
4. 4
   Waschenwashed with water

Vorschrift

0.07 g (0.00115 mol) of a 60% suspension of sodium hydride in mineral oil is added to a solution of 0.41 g (0.00114 mol) of ethyl 3-cyclopropylamino-2-(2,5-difluoro-4-pyrrol-1-ylbenzoyl)acrylate in 10 ml of anhydrous dioxane. The mixture is heated at 80° C. for 2 hours under a nitrogen atmosphere and left to cool, 30 ml of water are added and the precipitate is filtered off and washed with water to give 0.3 g of a product melting at 216°-9° C.

Quelle