Reaktion #466598

Reaktionsgleichung

6-Chloro-4-o-tolyl-nicotinamide

1-methyl-piperazine

→

6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide

Ausbeute 95.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe excess N-methyl-piperazine was removed under high vacuum
2. 2
   Filtrationthe residue was filtered on silica gel (eluent: dichloromethane)

Vorschrift

1.0 g (4.05 mMol) 6-Chloro-4-o-tolyl-nicotinamide in 9.0 ml 1-methyl-piperazine was heated to 100° C. for 2 hours. The excess N-methyl-piperazine was removed under high vacuum and the residue was filtered on silica gel (eluent: dichloromethane) to yield 1.2 g(95%) 6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide as a light yellow crystalline foam.

Quelle