Reaktion #466331

Reaktionsgleichung

Propargyl bromide

bis(2-methoxy-ethyl)amine

cesium carbonate

→

bis-(2-methoxy-ethyl)-prop-2-ynyl-amine

Ausbeute 77.9%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe inorganic salts were then filtered off
2. 2
   Sonstigethe solvent was removed
3. 3
   workup.DISSOLUTIONThe residue was dissolved in saturated sodium bicarbonate solution
4. 4
   Extraktionextracted with ethyl acetate
5. 5
   SonstigeThe organic extracts were then evaporated

Vorschrift

Propargyl bromide (17.8 g, 150 mmol) was added dropwise to a mixture of bis(2-methoxy-ethyl)amine (20 g, 150 mmol) and cesium carbonate (49 g, 150 mmol) in 350 mL of acetone. The mixture was stirred overnight under nitrogen at room temperature. The inorganic salts were then filtered off, and the solvent was removed. The residue was dissolved in saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic extracts were then evaporated to give 20 g of bis-(2-methoxy-ethyl)-prop-2-ynyl-amine: mass spectrum (m/e): M+H 172.

Quelle