Reaktion #466133

Reaktionsgleichung

KOH

m-aminoacetophenone

2-amino-4-chloro-6-methyl-pyrimidine

HCl

→

4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine

Ausbeute 78.5%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for 1 hour
3. 3
   Sonstigegave a light buff solid, which
4. 4
   Filtrationwas filtered out
5. 5
   Sonstigedried

Vorschrift

Compound No. 15 (CNI-1594): A suspension of m-aminoacetophenone (2.7 g) and 2-amino-4-chloro-6-methyl-pyrimidine (2.87 g) in 40 mL water was treated with 1.7 mL concentrated HCl and heated at reflux for 1 hour. Addition of 40 mL 1N KOH gave a light buff solid, which was filtered out and dried to give 3.8 g 4-(3-acetylphenyl)amino-2-amino-6-methylpyrimidine, mp 196-98° C.

Quelle