Reaktion #466108

Reaktionsgleichung

(±)-2-(acetylamino)-5-phenyl-pentanoic acid

→

(±)-2-Amino-5-phenyl-pentanoic acid

Lösungsmittel

hydrochloric acid

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 2 hours
2. 2
   Temperaturto cool
3. 3
   SonstigeA tan precipitate formed
4. 4
   Temperaturupon cooling
5. 5
   FiltrationThe solids were filtered off
6. 6
   Sonstigethe filtrate was rotary evaporated
7. 7
   Sonstigeto give a yellow gum
8. 8
   Filtrationgravity filtered
9. 9
   Temperaturto cool
10. 10
    FiltrationThe resulting precipitate was filtered off
11. 11
    Waschenwashed with water
12. 12
    Sonstigedried in vacuo
13. 13
    Sonstigeto give a yellow solid

Vorschrift

A stirred suspension of (±)-2-(acetylamino)-5-phenyl-pentanoic acid (0.5003 g, 0.002126 mol) in 2.8 M hydrochloric acid was refluxed for 2 hours, and the resulting brown solution was allowed to cool. A tan precipitate formed upon cooling. The solids were filtered off, and the filtrate was rotary evaporated to give a yellow gum. The gum was dissolved in hot water, gravity filtered, and allowed to cool. The mixture was made basic with 1 M sodium hydroxide to pH=5. The resulting precipitate was filtered off, washed with water, and dried in vacuo to give a yellow solid; yield 0.205 g (50%), mp=213-215° C.

Quelle