Reaktion #4659

Reaktionsgleichung

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

n-propyl bromide

→

solid

Ausbeute 70.1%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-propyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Ausbeute 70.1%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturis heated for 5 hours at 80°-90° C.
2. 2
   workup.WAITleft
3. 3
   Temperaturto cool
4. 4
   Sonstigethe precipitate formed
5. 5
   Filtrationis filtered off
6. 6
   Waschenwashed with water
7. 7
   Sonstigerecrystallized from ethanol

Vorschrift

A mixture of 3 g (0.01 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate, 2.8 g (0.02 mol) of potassium carbonate and 6 g (0.04 mol) of n-propyl bromide is heated for 5 hours at 80°-90° C. and left to cool, water is added and the precipitate formed is filtered off, washed with water and recrystallized from ethanol to give 2.4 g of a solid melting at 128°-130° C.

Quelle