Reaktion #46585

Reaktionsgleichung

2-Methoxyethylamine

2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

DIEA

→

title compound

Ausbeute 90.0%

2-Amino-5-bromo-3-[(2-methoxyethyl)aminomethyl]pyridine

Ausbeute 90.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthen was concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water
3. 3
   Extraktionthe solution was extracted with ethyl acetate
4. 4
   WaschenThe combined organic extracts were washed with brine
5. 5
   Trocknendried over Na2SO4
6. 6
   Einengenconcentrated

Vorschrift

2-Methoxyethylamine (1.49 mL, 17.16 mmole) was added to a solution of 2-amino-5-bromo-3-(bromomethyl)pyridine hydrobromide (1.49 g, 4.29 mmole) and DIEA (2.24 mL, 12.87 mmole) in CH2Cl2 (10 mL) at RT. The reaction was stirred overnight then was concentrated in vacuo. The residue was diluted with water and the solution was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated to afford the title compound (1.00 g, 90%) as a light brown liquid after drying in vacuo: MS (ES) m/e 260/262 (M+H)+.

Quelle