Reaktion #465829

ord-15651ddfeb7a4bfeac75a85666f6d74b

Reaktionsgleichung

C=CC(=O)NC(C)(C)c1ccc(CC#N)cc1
N-{1-[4-(cyanomethyl)phenyl]-1-methylethyl}acrylamide
c1c[nH]cn1
imidazole
C[N+](C)(C)Cc1ccccc1.[OH-]
benzyltrimethylammonium hydroxide
→
CC(C)(NC(=O)CCn1ccnc1)c1ccc(CC#N)cc1
N-{1-[4-(cyanomethyl)phenyl]1-methylethyl}-3-(imidazol-1-yl)propionamide

Edukte

C=CC(=O)NC(C)(C)c1ccc(CC#N)cc1
N-{1-[4-(cyanomethyl)phenyl]-1-methylethyl}acrylamide
c1c[nH]cn1
imidazole
C[N+](C)(C)Cc1ccccc1.[OH-]
benzyltrimethylammonium hydroxide

Reagenzien

Keine

Lösungsmittel

C1COCCO1
1,4-dioxane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

A mixture of N-{1-[4-(cyanomethyl)phenyl]-1-methylethyl}acrylamide (20.5 g), imidazole (6.11 g), benzyltrimethylammonium hydroxide (74 mg) and 1,4-dioxane (300 ml) gave N-{1-[4-(cyanomethyl)phenyl]1-methylethyl}-3-(imidazol-1-yl)propionamide as an oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06031109uspto-grants-2000_02