Reaktion #4658

Reaktionsgleichung

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

cyclopropylmethyl bromide

→

solid

Ausbeute 62.3%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-cyclopropylmethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

Ausbeute 62.3%

Lösungsmittel

dimethlformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITleft
2. 2
   Temperaturto cool
3. 3
   workup.WAITleft
4. 4
   Temperaturto cool
5. 5
   Sonstigethe precipitate formed
6. 6
   Filtrationis filtered off
7. 7
   Waschenwashed with water
8. 8
   Sonstigerecrystallized from ethanol

Vorschrift

A mixture of 3.6 g (0.012 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate and 4.15 g (0.03 mol) of potassium carbonate in 30 ml of dimethlformamide is heated for 30 minutes at 80° C. and left to cool, 8 g (0.06 mol) of cyclopropylmethyl bromide are added, the mixture is kept for 12 hours at 90° C. and left to cool, 80 ml of a water/ice mixture are added and the precipitate formed is filtered off, washed with water and recrystallized from ethanol to give 2.65 g of a solid melting at 125°-127° C.

Quelle