Reaktion #465554

Reaktionsgleichung

4-Carbomethoxy-2-(N-2-propylamino)phenylacetaldehyde dimethylacetal

hydrochloric acid

→

6-carbomethoxy-1-(2-propyl)indole

Ausbeute 97.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe solution was concentrated
2. 2
   workup.DISSOLUTIONthe residue dissolved in 50 mL of ethyl acetate
3. 3
   Waschenwashed with saturated sodium bicarbonate solution, dried organic layer over magnesium sulfate
4. 4
   Sonstigeevaporated

Vorschrift

4-Carbomethoxy-2-(N-2-propylamino)phenylacetaldehyde dimethylacetal (3.7 g, 13.15 mmole) was refluxed with 100 mL of 1N hydrochloric acid in methanol for 1 h. The solution was concentrated and the residue dissolved in 50 mL of ethyl acetate, washed with saturated sodium bicarbonate solution, dried organic layer over magnesium sulfate and evaporated to give 2.78 g of 6-carbomethoxy-1-(2-propyl)indole.

Quelle