Reaktion #465409

Reaktionsgleichung

3-dodecyloxy-2-decyloxy-1-triphenylmethoxypropane

p-toluenesulfonic acid

MeOH

→

3-dodecyloxy-2-decyloxy-1-propanol

Ausbeute 63.0%

Lösungsmittel

CHCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe residue was purified by column chromatography

Vorschrift

Detritylation of 3-dodecyloxy-2-decyloxy-1-triphenylmethoxypropane was accomplished using p-toluenesulfonic acid (0.9 g) in CHCl3 :MeOH (72 mL:36 mL) (stirred at room temperature for 48 h, added 10% sodium bicarbonate, extracted with CHCl3, dried over magnesium sulfate, and concentrated). The residue was purified by column chromatography using a gradient of hexanes:ethyl acetate (20:1 to 5:1) to give 3.5 g (63%) of pure 3-dodecyloxy-2-decyloxy-1-propanol.

Quelle