Reaktion #4653

Reaktionsgleichung

4-(2-hydroxyethoxy)phenol

epichlorohydrin

potassium carbonate

→

1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux temperature
2. 2
   FiltrationThe reaction mixture is filtered
3. 3
   Einengenthe filtrate is concentrated by evaporation under reduced pressure
4. 4
   Sonstigeis recrystallised from isopropanol

Vorschrift

With stirring, 13 g of crude 4-(2-hydroxyethoxy)phenol, 35 m of epichlorohydrin and 23.5 g of potassium carbonate are heated for 11/2 hours to reflux temperature. The reaction mixture is filtered and the filtrate is concentrated by evaporation under reduced pressure. The residual oil gradually congeals to a crystalline solid, which is recrystallised from isopropanol, affording 1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene with a melting point of 65°-67° C. Working up of the mother liquor yields further crystalline product.

Quelle