Reaktion #46523

Reaktionsgleichung

Acryloyl chloride

3-(methylaminomethyl)-1H-indole

Et3N

→

title compound

Ausbeute 80.7%

N-(1H-Indol-3-ylmethyl)-N-methylacrylamide

Ausbeute 80.7%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITThe reaction was held at 0° C. for ten minutes
2. 2
   EinengenThe solution was concentrated in vacuo
3. 3
   workup.ADDITIONthe residue was diluted with water
4. 4
   ExtraktionThe solution was extracted with ethyl acetate
5. 5
   Waschenthe combined organic extracts were washed with brine
6. 6
   Trocknendried over Na2SO4

Vorschrift

Acryloyl chloride (0.33 mL, 4.10 mmole) was added to a solution of 3-(methylaminomethyl)-1H-indole (0.60 g, 3.70 mmole) and Et3N (1.03 mL, 7.40 mmole) in CH2Cl2 (30 mL) at 0° C. The reaction was held at 0° C. for ten minutes, then was stirred overnight at RT. The solution was concentrated in vacuo and the residue was diluted with water. The solution was extracted with ethyl acetate, and the combined organic extracts were washed with brine and dried over Na2SO4. The title compound (0.64 g, 80%) was obtained as a light yellow solid: MS (ES) m/e 215 (M+H)+.

Quelle