Reaktion #464977

Reaktionsgleichung

sodium cyanide

1-benzylpiperid-4-one

piperidine hydrochloride

→

expected product

Ausbeute 95.4%

1-Benzyl-4-cyano-4-(piperid-1-yl)piperidine

Ausbeute 95.4%

Lösungsmittel

water

MeOH

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate formed
2. 2
   Filtrationis filtered off
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried under vacuum

Vorschrift

A solution of 5.3 g of sodium cyanide in 20 ml of water is added dropwise at RT to a solution of 18.9 g of 1-benzylpiperid-4-one and 12.16 g of piperidine hydrochloride in 25 ml of MeOH and 25 ml of water and the mixture is stirred for 48 hours at RT. The precipitate formed is filtered off, washed with water and dried under vacuum to give 27 g of the expected product.

Quelle