Reaktion #46492

Reaktionsgleichung

2-amino-3-(bromomethyl)-5-bromopyridine hydrobromide salt

methylamine

→

title compound

Ausbeute 80.0%

2-Amino-5-bromo-3-(methylaminomethyl)pyridine

Ausbeute 80.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction solution was concentrated
2. 2
   Extraktionextracted with EtOAc (2×100 mL)
3. 3
   WaschenThe combined organic phases were washed with H2O
4. 4
   Trocknendried over Na2SO4
5. 5
   Einengenconcentrated
6. 6
   SonstigePurification on silica gel

Vorschrift

A solution of the 2-amino-3-(bromomethyl)-5-bromopyridine hydrobromide salt (prepared above) in 40% aqueous methylamine (50 mL) and THF (50 mL) was stirred at RT overnight in a pressure bottle. The reaction solution was concentrated and extracted with EtOAc (2×100 mL). The combined organic phases were washed with H2O, dried over Na2SO4 and concentrated. Purification on silica gel afforded the title compound (4.25 g, 80%) as a yellow oil: MS (ES) m/e 217 (M+H)+.

Quelle