Reaktion #46491

Reaktionsgleichung

2-amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide

→

title compound

Ausbeute 172.4%

2-Amino-5-bromo-3-(bromomethyl)pyridine hydrobromide

Ausbeute 172.4%

Lösungsmittel

HBr

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 12 hrs
3. 3
   Temperaturduring heating
4. 4
   TemperaturThe reaction mixture was cooled
5. 5
   Sonstigea crystalline precipitate formed
6. 6
   FiltrationThis was filtered
7. 7
   Waschenwashed with ethyl acetate and air
8. 8
   Sonstigedried

Vorschrift

A suspension of 2-amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide (289 g, 1.02 mole) in 48% aqueous HBr (2.9 L) was heated at reflux for 12 hrs. Complete solution occurred during heating. The reaction mixture was cooled and a crystalline precipitate formed. This was filtered and washed with ethyl acetate and air dried to give the title compound (305 g, 86%).

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