Reaktion #46484

Reaktionsgleichung

diethyl ether

bromine

2-(4-acetylphenoxy)acetic acid

Bromine

→

2-(4-(2-bromoacetyl)phenoxy)acetic acid

Ausbeute 46.0%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGsolution was stirred for an additional 16 hours
2. 2
   SonstigeVolatiles were removed under reduced pressure
3. 3
   Sonstigeto provide a brown solid which

Vorschrift

2-(4-acetylphenoxy)acetic acid (2.81 g, 14.5 mmol) was dissolved in acetic acid (100 mL) and treated with bromine (740 μL, 14.5 mmol) and stirred 48 hours. Bromine (370 mL, 7.25 mmol) was added and solution was stirred for an additional 16 hours. Volatiles were removed under reduced pressure to provide a brown solid which was titurated with diethyl ether to provide 2-(4-(2-bromoacetyl)phenoxy)acetic acid (1.82 g) as a light brown solid.

Quelle