Reaktion #464693

ord-f3458a4ceac644c19c71b2798b5065d6

Reaktionsgleichung

O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
CNCc1ccccc1
N-methyl benzylamine
CCc1ncc[nH]1
2-ethylimidazole
[Cl][Sn][Cl]
tin (II) chloride
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
→
CCc1ncc2c(=O)[nH]c3c(N(C)Cc4ccccc4)ncnc3n12
9-Ethyl-4-[(phenylmethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one

Edukte

O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
CNCc1ccccc1
N-methyl benzylamine
CCc1ncc[nH]1
2-ethylimidazole
[Cl][Sn][Cl]
tin (II) chloride
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N-methyl benzylamine, reaction with 2-ethylimidazole, reduction with tin (II) chloride and cyclization with carbonyldiimidazole.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06025489uspto-grants-2000_02