Reaktion #464691

ord-83047f3e8901494e9a721f7f8a623fa2

Reaktionsgleichung

CCc1ncc[nH]1
2-ethylimidazole
[Cl][Sn][Cl]
tin (II) chloride
O=C(n1ccnc1)n1ccnc1
carbonyidiimidazole
O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
CNCCc1ccccn1
2-(2-(methylamino)ethyl)pyridine
→
CCc1ncc2c(=O)[nH]c3c(N(C)CCc4ccccn4)ncnc3n12
9-Ethyl-4-[(2-(pyridin-2-yl)ethyl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one

Edukte

CCc1ncc[nH]1
2-ethylimidazole
[Cl][Sn][Cl]
tin (II) chloride
O=C(n1ccnc1)n1ccnc1
carbonyidiimidazole
O=[N+]([O-])c1c(Cl)ncnc1Cl
4,6-dichloro-5-nitropyrimidine
CNCCc1ccccn1
2-(2-(methylamino)ethyl)pyridine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 2-(2-(methylamino)ethyl)pyridine followed by reaction with 2-ethylimidazole, reduction with tin (II) chloride and cyclization with carbonyidiimidazole.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06025489uspto-grants-2000_02