Reaktion #46458

Reaktionsgleichung

2-Bromo-4-methyl-6-iodophenol

cinnamyl bromide

Diisopropylethylamine

→

1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene

Ausbeute 101.2%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe DMF was removed under vacuum, and 1M HCl
2. 2
   workup.ADDITIONwas added until the residue
3. 3
   ExtraktionThe mixture was extracted with ethyl acetate
4. 4
   Trocknenthe combined organic phase was dried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated under reduced pressure

Vorschrift

2-Bromo-4-methyl-6-iodophenol (7.82 gm, 25 mmol) and cinnamyl bromide (4.93 g, 25 mmol) were added to DMF (20 ml). Diisopropylethylamine (5.3 ml, 30.4 mmol) was added and the mixture heated to 60° C. for 15 minutes and then allowed stir for 16 hours at room temperature. The DMF was removed under vacuum, and 1M HCl was added until the residue was acidic. The mixture was extracted with ethyl acetate, and the combined organic phase was dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give 1-bromo-3-iodo-5-methyl-2-(3-phenylallyloxy)-benzene (10.86 g, 100% yield).

Quelle