Reaktion #46452

Reaktionsgleichung

EtOAc H2O

1-[4-(3-benzoyl-1H-indol-7-yl)-piperazin-1-yl]-2,2,2-trifluoro-ethanone

NaBH4

→

3-benzyl-7-piperazin-1-yl-1H-indole

Ausbeute 126.5%

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter heating
2. 2
   Temperaturat reflux for 3 days
3. 3
   SonstigeThe organic layer was separated
4. 4
   Waschenwashed with water and brine
5. 5
   TrocknenAfter drying over MgSO4
6. 6
   Einengenthe organic fraction was concentrated in vacuo

Vorschrift

To a solution of 1-[4-(3-benzoyl-1H-indol-7-yl)-piperazin-1-yl]-2,2,2-trifluoro-ethanone (638 mg, 1.59 mmol) in isopropanol (30 ml) was added NaBH4 (0.12 g, 3.17 mmol). After heating at reflux for 3 days, the reaction mixture was allowed to cool to room temperature and poured into a mixture of EtOAc/H2O. The organic layer was separated and washed with water and brine. After drying over MgSO4, the organic fraction was concentrated in vacuo to give crude 3-benzyl-7-piperazin-1-yl-1H-indole as an oil (586 mg) which was used without further purification.

Quelle