Reaktion #46401

Reaktionsgleichung

5-nitro-oxindole

→

5-amino-oxindole

Ausbeute 50.5%

Lösungsmittel

dimethylacetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigefor 16 h
2. 2
   SonstigeThe catalyst was removed by filtration
3. 3
   workup.ADDITIONthe filtrate was diluted with ether (2 L)

Vorschrift

To a solution of 5-nitro-oxindole (25 g) in 120 mL of dimethylacetamide in a Parr bottle was added 10% Pd/C (0.5 g). The mixture was hydrogenated (40 psi H2) for 16 h. The catalyst was removed by filtration and the filtrate was diluted with ether (2 L) to provide 5-amino-oxindole (10.5 g; 50%).

Quelle