Reaktion #46395

Reaktionsgleichung

ethyl 4-pyrazole carboxylate

potassium carbonate

1-bromo-3-phenylpropane

→

ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe suspension was refluxed overnight
2. 2
   Sonstigeafter which the solvent was removed under reduced pressure
3. 3
   SonstigeThe residue was partitioned between ethyl acetate and water
4. 4
   Trocknenthe organic layer dried over magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   Sonstigethe filtrate evaporated under reduced pressure
7. 7
   Sonstigeto give an oil, which
8. 8
   Sonstigewas purified by preparative TLC

Vorschrift

To a solution of ethyl 4-pyrazole carboxylate (3.57 mmol) in acetone (30 ml) was added potassium carbonate (35.7 mmol) and 1-bromo-3-phenylpropane (3.57 mmol). The suspension was refluxed overnight, after which the solvent was removed under reduced pressure. The residue was partitioned between ethyl acetate and water, the organic layer dried over magnesium sulfate, filtered, and the filtrate evaporated under reduced pressure to give an oil, which was purified by preparative TLC, to give ethyl 1-(3-phenylpropyl)pyrazole-4-carboxylate.

Quelle