Reaktion #4638

Reaktionsgleichung

5-(2-methyl-2-nitropropoxy)salicylamide

→

5-(2-amino-2-methylpropoxy)salicylamide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige80 bar over 5 g of Raney nickel until hydrogen absorption
2. 2
   FiltrationBy filtration and concentration of the filtrate
3. 3
   Sonstigeby evaporation

Vorschrift

11.5 g 5-(2-methyl-2-nitropropoxy)salicylamide are hydrogenated in 150 ml of methanol at 40°-50° and 80 bar over 5 g of Raney nickel until hydrogen absorption ceases. By filtration and concentration of the filtrate by evaporation, crude 5-(2-amino-2-methylpropoxy)salicylamide is obtained, which, after standing for a relatively long period, crystallises from isopropanol and melts at 115°-117°.

Quelle