Reaktion #46377

ord-30d177a5a9b14b29988f36392bd58c77

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCCC[C@H]1CN
(S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
N#Cc1cccnc1Cl
2-chloro-3-cyanopyridine
→
CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1ncccc1C#N
title compound
Ausbeute 28.9%
CC(C)(C)OC(=O)N1CCCC[C@H]1CNc1ncccc1C#N
(S)-2-[(3-Cyano-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid tert butyl ester
Ausbeute 28.9%

Edukte

CC(C)(C)OC(=O)N1CCCC[C@H]1CN
(S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester
N#Cc1cccnc1Cl
2-chloro-3-cyanopyridine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound (0.66 g) was prepared from (S)-2-aminomethyl-piperidine-1-carboxylic acid tert-butyl ester (1.55 g) and 2-chloro-3-cyanopyridine (1.0 g) according to the method of D28.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07741329B2uspto-grants-2010_06