Reaktion #463453

Reaktionsgleichung

4-(5-trifluoromethyl-tetrazol-1-yl)-phenol

hexamethylenetetramine

trifluoroacetic acid

→

title compound

2-Hydroxy-5-(5-trifluoromethyl-tetrazol-1-yl)-benzaldehyde

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was quenched with 2N sulphuric acid (250 ml)
2. 2
   Extraktionextracted with ether (3×250 ml))
3. 3
   TrocknenThe combined organics were dried (Na2SO4)
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeto give a dark yellow oil
6. 6
   SonstigePurification by FCC (hexane/ether (2:1))

Vorschrift

A solution of 4-(5-trifluoromethyl-tetrazol-1-yl)-phenol (45 mmol) in trifluoroacetic acid (200 ml) and hexamethylenetetramine (186.9 mmol) was heated at 100° under nitrogen for 16 h. The reaction mixture was quenched with 2N sulphuric acid (250 ml) and extracted with ether (3×250 ml)). The combined organics were dried (Na2SO4) and evaporated to give a dark yellow oil. Purification by FCC (hexane/ether (2:1)) afforded the title compound (8.8 g) as a pale yellow solid.

Quelle