Reaktion #463287

Reaktionsgleichung

chloroformic acid benzyl ester

6-aminohexan-1-ol

sodium hydrogen carbonate

→

6-(N-benzyloxycarbonylamino)hexan-1-ol

Lösungsmittel

acetone

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated to approximately 70 ml
2. 2
   Filtrationthe white precipitate is filtered off
3. 3
   Waschenwashed with approximately 20 ml of water
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Filtrationthe magnesium sulfate is filtered off
6. 6
   Einengenthe residue is concentrated to dryness by evaporation

Vorschrift

7.06 ml (47 mmol) of chloroformic acid benzyl ester are added dropwise to a solution of 5.52 g (47 mmol) of 6-aminohexan-1-ol and 3.95 g (47 mmol) of sodium hydrogen carbonate in 100 ml of acetone and 50 ml of water. The mixture is stirred at room temperature for 18 hours and concentrated to approximately 70 ml, and the white precipitate is filtered off, washed with approximately 20 ml of water, taken up in 250 ml of methylene chloride and dried over magnesium sulfate; the magnesium sulfate is filtered off and the residue is concentrated to dryness by evaporation. 6-(N-benzyloxycarbonylamino)hexan-1-ol is obtained in the form of white crystals having a melting point of 58°-60°.

Quelle