Reaktion #46328

Reaktionsgleichung

Dihexylamine

3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole

→

title intermediate

Ausbeute 72.4%

4-(N,N-Di-n-hexylamino)-3-ethoxy-1,1-dioxo-1,2,5-thiadiazole

Ausbeute 72.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under reduced pressure
2. 2
   Sonstigethe residue absorbed onto silica gel
3. 3
   Sonstigeand purified by flash column chromatography (silica, hexane:EtOAc 3:1)

Vorschrift

Dihexylamine (90 mg, 0.48 mmol) was added to a solution of 3,4-diethyloxy-1,1-dioxo-1,2,5-thiadiazole (100 mg, 0.48 mmol) in ethanol (5 mL) and the reaction stirred overnight at room temperature. The solvent was removed under reduced pressure and the residue absorbed onto silica gel; and purified by flash column chromatography (silica, hexane:EtOAc 3:1) to yield the title intermediate (120 mg, 72%).

Quelle