Reaktion #462953

Reaktionsgleichung

2,2,6,6-tetramethyl-4-piperidone

butylamine

hydrogen

→

title compound

Ausbeute 95.0%

2,2,6,6-Tetramethyl-4-butylaminopiperidine

Ausbeute 95.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAt the end of this time, the platinum catalyst was filtered off
2. 2
   Sonstigethe solvent was removed from the filtrate by distillation under reduced pressure
3. 3
   workup.DISTILLATIONafter which the residue was further purified by distillation under reduced pressure

Vorschrift

155 g of 2,2,6,6-tetramethyl-4-piperidone and 80.0 g of butylamine were dissolved in 300 ml of methanol, and then 2.0 g of platinum oxide were added to the resulting solution, after which the solution was shaken under a pressure of 3 atmospheres of hydrogen in a medium-pressure hydrogenation apparatus at room temperature for 5 hours. At the end of this time, the platinum catalyst was filtered off, and the solvent was removed from the filtrate by distillation under reduced pressure, after which the residue was further purified by distillation under reduced pressure, to yield 201.5 g of the title compound as an oil boiling at 100° to 101° C./5 mmHg (667 Pa).

Quelle