Reaktion #462725

Reaktionsgleichung

2-(carboethoxy)indan

potassium hydroxide

→

2-indancarboxylic acid

Ausbeute 69.1%

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePartition between water (150 mL) and ethyl ether (2×150 mL)
2. 2
   ExtraktionExtract with methylene chloride (2×150 mL)
3. 3
   Trocknendry (Na2SO4)
4. 4
   Sonstigeevaporate the solvent in vacuo

Vorschrift

Dissolve 2-(carboethoxy)indan (6.49 g, 34.1 mmol) in ethanol (95%, 150 mL) and water (75 mL). Add potassium hydroxide (9.5 g, 0.17 mol) and stir at room temperature for 1 hour. Partition between water (150 mL) and ethyl ether (2×150 mL). Acidify the aqueous phase with hydrochloric acid to pH 1. Extract with methylene chloride (2×150 mL), dry (Na2SO4) and evaporate the solvent in vacuo to give 2-indancarboxylic acid as a tan solid (3.82 g, 69%).

Quelle