Reaktion #462365

Reaktionsgleichung

Trifluoromethylsulfenyl chloride

2-(p-chlorophenyl)pyrrole

sodium carbonate

→

title product

2-(p-Chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole

Lösungsmittel

ether

water ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic phase is separated
2. 2
   Waschenwashed with brine
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

Trifluoromethylsulfenyl chloride is bubbled into a solution of 2-(p-chlorophenyl)pyrrole (0.5 g, 0.00281 mol) and sodium carbonate (0.36 g, 0.00338 mol) in ether at -30° C. under nitrogen. The reaction mixture is stirred for 1/2 hour and diluted with a water/ether mixture. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title product as a purple solid (0.78 g, mp 34°-39° C.) which is identified by 1HNMR and 13CNMR spectral analyses.

Quelle