Reaktion #46235

Reaktionsgleichung

4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-2-yl)benzenesulfonic acid

SOCl2

DMF

→

4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropane-carboxamido)pyridin-2-yl)benzene-1-sulfonyl chloride

Lösungsmittel

POCl3

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatiles were evaporated
2. 2
   Sonstigere-evaporated with chloroform-toluene
3. 3
   workup.ADDITIONThe residual brown oil was diluted with chloroform (22 mL)

Vorschrift

4-(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-2-yl)benzenesulfonic acid (1.9 g, 4.3 mmol) was dissolved in POCl3 (30 mL) followed by the addition of SOCl2 (3 mL) and DMF (100 μl). The reaction mixture was heated at 70-80° C. for 15 min. The volatiles were evaporated and then re-evaporated with chloroform-toluene. The residual brown oil was diluted with chloroform (22 mL) and used for sulfonylation immediately. ESI-MS m/z calc. 456.0. found 457.1 (M+1).

Quelle